What to do if you suspect that there is an ethical problem in a received manuscript?

The reviewer (or editor) communicates concern about a possible ethical problem in the manuscript. For example, lack of approval from the ethics committee, or concerns about patient consent, patient protection, or animal experiments.

So:

Thank the reviewer and let them know that you plan to investigate
The author provides the relevant details.There can be two answers:

A. Satisfactory response

Apologize and continue with the review process

B. No response or unsatisfactory response

Inform the author that the review process is suspended until the case is resolved Communicate your concern to the author's center or the person responsible for the center's research standards.
From here two actions or solutions are derived:

The problem is resolved satisfactorily, then:

Inform the reviewer of the results of the case

2. No response or unsatisfactory response, then:

Contact the center every 3-6 months to try to complete your research.

If:

a) The problem is solved satisfactorily, then:

Inform the reviewer of the results of the case.

b) No response or unsatisfactory response

Refer the case to other competent authorities
Inform the reviewer of the results of the case